Key result
Serum Angiopoietin-2 levels were independently associated with cardiovascular risk factors, including fasting blood glucose and triglycerides, in drug-controlled type 2 diabetic subjects.
Why the study?
Is serum Angiopoietin-2 level associated with cardiovascular risk factors in drug-controlled hypertensive type 2 diabetic subjects?
Cross-Sectional
Is serum Angiopoietin-2 level associated with cardiovascular risk factors in drug-controlled hypertensive type 2 diabetic subjects?
Serum Angiopoietin-2 levels are independently associated with fasting blood glucose and triglycerides in hypertensive type 2 diabetic patients, suggesting potential utility as a biomarker for cardiovascular risk stratification.
Ang-2 associates with CV risks in hypertensive T2D; hypothesis-generating for stratification, needs prospective validation before any clinical role.
OBJECTIVES: This observational cross-sectional study aimed to investigate the relationship between serum Angiopoietin-2 (Ang-2) levels and cardiovascular (CVD) risk factors in drug controlled hypertensive diabetic subjects without cardiovascular complications. METHODS: All subjects were evaluated for fasting blood glucose (FBG), HbA1c, liver enzymes, lipid profile and serum Ang-2. RESULTS: Mean serum Ang-2 level was significantly higher in hypertensive diabetic subjects. In bivariate analysis in diabetic subjects with cardiovascular risk factors, Ang-2 positively correlated with waist circumference, body mass index (BMI), systolic blood pressure (SBP), FBG, HbA1c and triglycerides. In multivariate linear regression analysis, this association remained significant with FBG and triglycerides. Ang-2 levels were independently associated with CVD risk factors in drug controlled Type 2 diabetes (T2D) subjects. CONCLUSIONS: Further detailed studies in larger population with more attention is needed to consider Ang-2 level as a tool for CVD risk stratification in hypertensive diabetic subjects.
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Siddiqui et al. (2018) conducted a cross-sectional in Hypertensive type 2 diabetes. Serum Angiopoietin-2 (Ang-2) levels was evaluated on Association with cardiovascular risk factors. Serum Angiopoietin-2 levels were independently associated with cardiovascular risk factors, including fasting blood glucose and triglycerides, in drug-controlled type 2 diabetic subjects.
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