What question did this study set out to answer?

May 15, 2023Scientific ReportsOpen Access

Neutrophil to high-density lipoprotein cholesterol ratio as the risk mark in patients with type 2 diabetes combined with acute coronary syndrome: a cross-sectional study

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Why the study?

Few studies have investigated the role of the neutrophil to high-density lipoprotein cholesterol ratio in assessing the risk of ACS in patients with T2DM.

Does the neutrophil to high-density lipoprotein cholesterol ratio (NHR) predict the presence of acute coronary syndrome in patients with type 2 diabetes mellitus?

Key Points

To assess the predictive and diagnostic utility of the neutrophil to high-density lipoprotein cholesterol ratio (NHR) for acute coronary syndrome in patients with type 2 diabetes mellitus.
Cross-sectional study of 379 hospitalized individuals: 211 type 2 diabetes patients with acute coronary syndrome and 168 type 2 diabetes controls recruited from Xiangya Hospital between June 2020 and December 2021.
Demographic details, biochemical markers, and echocardiographic parameters were collected and analyzed using multivariable logistic regression, Spearman rank correlation, and ROC curve analyses.
NHR was significantly higher in diabetic patients with acute coronary syndrome than in diabetic controls (p < 0.001) and remained an independent risk factor after adjusting for BMI, alcohol use, and hypertension history (OR 1.221, p = 0.0126).
NHR positively correlated with cardiac injury markers including cTnI (r = 0.437, p < 0.001) and CK-MB (r = 0.447, p < 0.001), while negatively correlating with ejection fraction (r = -0.327, p < 0.001).
ROC analysis showed an NHR cutoff of ≥ 4.32 yielded a sensitivity of 65.45% and specificity of 66.19% for predicting acute coronary syndrome in diabetic patients (AUC = 0.722, p < 0.001), with stronger diagnostic value in ST-segment elevated cases (p < 0.001).

Structured PICO

Does the neutrophil to high-density lipoprotein cholesterol ratio (NHR) predict the presence of acute coronary syndrome in patients with type 2 diabetes mellitus?

Population

379 hospitalized patients with type 2 diabetes mellitus (T2DM), comprising 211 with acute coronary syndrome (ACS) and 168 without ACS, collected from 6/2020 to 12/2021 at Xiangya Hospital.

Intervention

Neutrophil to high-density lipoprotein cholesterol ratio (NHR) assessment

Comparator

T2DM patients without ACS (control group)

Outcome

Presence of acute coronary syndrome (ACS)surrogate

The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is a readily available biomarker that independently correlates with myocardial injury and predicts the presence of acute coronary syndrome in patients with type 2 diabetes.

Discussion

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Implication

NHR may aid ACS risk stratification in T2DM without changing practice; leaves open incremental value and need for prospective validation.

Cite This Study

Ren et al. (2023) studied this question.

synapsesocial.com/papers/6a0fdcaed13714ec96feb636 https://doi.org/10.1038/s41598-023-35050-6

Topics

Hypertension management

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Neutrophil to high-density lipoprotein cholesterol ratio as the risk mark in patients with type 2 diabetes combined with acute coronary syndrome: a cross-sectional study

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Neutrophil to high-density lipoprotein cholesterol ratio as the risk mark in patients with type 2 diabetes combined with acute coronary syndrome: a cross-sectional study

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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