Key result
Mean serum fibrinogen levels were significantly higher in patients with NSTEMI (417.2 mg/dl) compared to other acute coronary syndrome subtypes (P=0.002).
Observational (n=200)
No
Serum fibrinogen levels are significantly higher in NSTEMI and ACS patients with ST-T changes, suggesting its utility as a marker of severity or risk in acute coronary syndrome.
Fibrinogen may mark NSTEMI severity in ACS; cross-sectional data leave open its prognostic utility pending validation.
OBJECTIVE: Serum fibrinogen level (SFL) is thought to be one of the risk factors for coronary artery disease (CAD). The purpose of this study was to measure the SFL in patients with acute coronary syndrome (ACS). METHODS: This study was performed in patients with ACS, admitted in Shahid Beheshti Hospital, Babol, Iran, from February 2005 to June 2006. Two hundred patients with ACS were divided into 4 groups: Group I - ST elevated myocardial infarction (STEMI); Group II - non-ST elevated myocardial infarction (NSTEMI); Group III - unstable angina (U/A) with ST-T change; and Group IV - U/A without ST-T change. Each group includes 50 patients. Twenty-four hours after admission, the SFL was measured using chromatography methods. The data were collected and analyzed. RESULTS: The mean SFL per mg/dl in each group are: Group I - 377.8 +/- 28, Group II - 417.2 +/- 26.8, Group III - 335.4 +/- 19.8, and Group IV - 305.1 +/- 13.8. The SFL in Group II was significantly higher than the other groups (p=0.002). The SFL in Group II was higher than in Group III (p=0.02), and much higher than in Group IV (p=0.000). The SFL in Group III was more than in Group IV (p=0.018). CONCLUSION: The results show that SFL is an important marker in patients with ACS, with ST-T change.
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Omran et al. (2007) conducted an observational in Acute coronary syndrome (n=200). NSTEMI vs. Other acute coronary syndrome subtypes was evaluated on Serum fibrinogen level at 24 hours after admission (p=0.002). Mean serum fibrinogen levels were significantly higher in patients with NSTEMI (417.2 mg/dl) compared to other acute coronary syndrome subtypes (P=0.002).
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