Key result
Higher serum creatinine was significantly associated with the development of late cytomegalovirus infection (≥ 2 years post-transplant) in kidney transplant recipients (OR 1.004).
Why the study?
Late CMV infection following kidney transplantation is uncommon, and its risk factors and outcomes may differ from earlier infection.
Population
Kidney transplant recipients between 2009 and 2019
Comparison
No CMV infection vs early CMV infection vs late CMV infection
Design
Single-centre retrospective study
Authors
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Elevated creatinine may flag late CMV risk in kidney transplant recipients; hypothesis-generating and should not yet change prophylaxis practice.
Cohort (n=780)
No
Odds Ratio: 1.004 (95% CI 1.001–1.006)
p-value: p=0.003
Renal dysfunction, rather than traditional risk factors like donor-recipient serostatus, is a key predictor of late CMV infection (≥2 years) after kidney transplantation.
Barraclough et al. (2025) conducted a cohort in Kidney Transplantation (n=780). Serum creatinine (renal dysfunction) vs. Lower serum creatinine was evaluated on Late CMV infection (≥ 2 years post-transplant) (OR 1.004, 95% CI 1.001-1.006, p=0.003). Higher serum creatinine was significantly associated with the development of late cytomegalovirus infection (≥ 2 years post-transplant) in kidney transplant recipients (OR 1.004).
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