Key result
Incubation with lipolytic products such as oleic acid or monoolein did not release active lipoprotein lipase from binding sites at the surface of isolated cardiac myocytes or perfused rat hearts.
Lipolytic products such as free fatty acids do not release active lipoprotein lipase from binding sites on cardiac myocytes or capillary endothelial cells.
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Does not support lipolytic products releasing cardiac LPL in rats; leaves open in vivo mechanisms and human relevance.
Rodrigues et al. (1992) studied this question. Lipolytic products (oleic acid or monoolein) vs. Control medium was evaluated on Lipoprotein lipase (LPL) activity in the medium or perfusate. Incubation with lipolytic products such as oleic acid or monoolein did not release active lipoprotein lipase from binding sites at the surface of isolated cardiac myocytes or perfused rat hearts.
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