Key result
Preoperative hyperuricemia in patients undergoing isolated carotid endarterectomy was associated with significantly longer carotid cross-clamp times (12.4 vs 11.1 minutes, p=0.034) and increased postoperative bleeding compared to normouricemic patients.
Why the study?
Whether uric acid is an independent predictor of cardiovascular disease remains controversial, and its role in outcomes after carotid artery endarterectomy is unclear.
Does hyperuricemia worsen prognosis and increase complications in patients undergoing isolated carotid endarterectomy?
Cohort (n=120)
No
Does hyperuricemia worsen prognosis and increase complications in patients undergoing isolated carotid endarterectomy?
Mean Difference: 1.3
Absolute Event Rate: 12.4% vs 11.1%
p-value: p=0.034
Hyperuricemia may be associated with increased operative complexity and specific postoperative complications in patients undergoing carotid endarterectomy, highlighting its potential role as a metabolic risk factor.
Hyperuricemia may flag higher procedural risk in carotid endarterectomy; leaves open whether lowering uric acid improves outcomes.
Background: Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease, with many studies in favor and others against. The results of this study are expected to enhance our knowledge regarding the role of uric acid level on outcomes of patients with carotid artery endarterectomy and thus can be used by clinician in determining patient's prognosis.
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Haydar Yaşa (2020) conducted a cohort in Carotid Artery Disease (n=120). Hyperuricemia vs. Normouricemia was evaluated on Carotid cross-clamp time (minutes) (p=0.034). Preoperative hyperuricemia in patients undergoing isolated carotid endarterectomy was associated with significantly longer carotid cross-clamp times (12.4 vs 11.1 minutes, p=0.034) and increased postoperative bleeding compared to normouricemic patients.
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