Key result
Pregnancy in women with heart disease was associated with a perinatal mortality rate of 13.5 per 1000 deliveries, similar to the overall hospital rate, with no maternal deaths observed.
Observational (n=106)
No
The study highlights a shift in the pattern of heart disease during pregnancy, with congenital heart disease becoming significantly more common than rheumatic heart disease, and demonstrates excellent maternal and fetal outcomes.
Answers are grounded in this paper and cite their sources.
Supports favorable outcomes in contemporary heart disease pregnancies; leaves open generalizability beyond single-center observational data.
SummaryBetween 1974 and 1982 at the Leicester Royal Infirmary Maternity Hospital 106 women with heart disease had 148 pregnancies. During this time the total number of deliveries was 45 970 and the incidence of heart disease was 0·32 per cent, which is lower than in previous studies. The perinatal mortality was 13·5/1000 deliveries which was virtually identical to the overall hospital perinatal mortality rate during the same time. There were no maternal deaths.Congenital heart disease was three times more common than rheumatic heart disease.Only one patient with congenital heart disease developed bacterial endocarditis; none of those with rheumatic heart disease did so.Almost half the patients with congenital heart disease had undergone corrective surgery before pregnancy. This and the declining incidence of rheumatic heart disease are considered to be the main reasons for improved fetal survival.
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Macnab et al. (1985) conducted an observational in Heart disease in pregnancy (n=106). Heart disease vs. Overall hospital population was evaluated on Perinatal mortality. Pregnancy in women with heart disease was associated with a perinatal mortality rate of 13.5 per 1000 deliveries, similar to the overall hospital rate, with no maternal deaths observed.
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