What is the clinical evidence from this study?

Study design: Observational. Population: Congenital or acquired heart disease in pregnancy (n=139). Intervention: Severe maternal heart disease vs. Mild maternal heart disease. Primary outcome: Clinical-instrumental worsening of maternal heart disease during pregnancy.

What does this research mean for the field?

The severity of maternal heart disease, as stratified by the modified World Health Organization classification, positively correlates with the risk of maternal cardiovascular worsening, need for intensive care, and adverse fetal outcomes such as prematurity and low birth weight, but not with the incidence of obstetric complications. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate clinical-instrumental trajectories along with maternal, obstetrical, and fetal complications across different severity levels of heart disease during pregnancy.

September 15, 2026European Heart Journal Supplements

Pregnancy and Heart Disease: A Single–centre Study

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Key result

Baseline maternal heart disease severity correlates with worsening during pregnancy in up to 46% of cases.

n=139

Why the study?

Pregnancy involves cardiovascular changes that can pose risks for patients with congenital or acquired heart disease.

Population

139 patients with congenital or acquired heart disease across 287 pregnancies

Comparison

Three groups categorized by the modified World Health Organization classification

Design

Single-centre retrospective observational study

Authors

CNC NannelliAzienda Ospedaliera Universitaria Integrata Verona PFP FerreroAzienda Ospedaliera Universitaria Integrata Verona GLG LucianiAzienda Ospedaliera Universitaria Integrata Verona

Discussion

Member takes

Implication

Severity-stratified worsening supports risk counseling in pregnant cardiac patients; leaves open prospective validation of mWHO-guided interventions.

Key Points

To evaluate clinical-instrumental trajectories along with maternal, obstetrical, and fetal complications across different severity levels of heart disease during pregnancy.
Conducted a retrospective observational study of 287 pregnancies across 139 patients with congenital or acquired heart disease at a single pediatric cardiology center from 1970 to 2024.
Stratified the patient cohort into three severity tiers using the modified World Health Organization classification system to compare clinical worsening, therapeutic interventions, and complication rates.
Clinical-instrumental worsening of maternal heart disease occurred in 8% of the mild group, 32% of the moderate group, and 46% of the severe group.
Severe maternal heart disease was associated with higher rates of intensified cardiac therapy, postpartum intensive care admission, cesarean delivery, abortion, preterm birth, and low birth weight.
Rates of obstetric complications were similar across severity groups, and newborn heart disease recurrence did not correlate with maternal disease severity.

Study Design

Type

Observational (n=139)

Multicenter

Structured PICO

Population

139 pregnant women with congenital or acquired heart disease (accounting for 287 pregnancies) evaluated retrospectively from 1970 to 2024.

Outcome

Clinical-instrumental trends, maternal gestational complications, obstetrical and fetal complications

Main Result

Absolute Event Rate: 46% vs 8%

Pregnancy in women with heart disease carries risks of clinical worsening and complications that correlate directly with the baseline severity of the cardiac condition, emphasizing the need for multidisciplinary management.

Cite This Study

Nannelli et al. (2026) conducted an observational in Congenital or acquired heart disease in pregnancy (n=139). Severe maternal heart disease vs. Mild maternal heart disease was evaluated on Clinical-instrumental worsening of maternal heart disease during pregnancy. Clinical-instrumental worsening of maternal heart disease during pregnancy correlated with baseline severity, occurring in 8% of mild, 32% of moderate, and 46% of severe cases.

synapsesocial.com/papers/6aa9017deed42882c1fc1954 https://doi.org/10.1093/eurheartjsupp/suag058.266

View Full Paper

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September 15, 2026European Heart Journal Supplements

Pregnancy and Heart Disease: A Single–centre Study

View Full Paper

Ask AI

Bookmark

Key result

Baseline maternal heart disease severity correlates with worsening during pregnancy in up to 46% of cases.

n=139

Why the study?

Pregnancy involves cardiovascular changes that can pose risks for patients with congenital or acquired heart disease.

Population

139 patients with congenital or acquired heart disease across 287 pregnancies

Comparison

Three groups categorized by the modified World Health Organization classification

Design

Single-centre retrospective observational study

Authors

CNC NannelliAzienda Ospedaliera Universitaria Integrata Verona PFP FerreroAzienda Ospedaliera Universitaria Integrata Verona GLG LucianiAzienda Ospedaliera Universitaria Integrata Verona

Discussion

Member takes

Implication

Severity-stratified worsening supports risk counseling in pregnant cardiac patients; leaves open prospective validation of mWHO-guided interventions.

Key Points

To evaluate clinical-instrumental trajectories along with maternal, obstetrical, and fetal complications across different severity levels of heart disease during pregnancy.
Conducted a retrospective observational study of 287 pregnancies across 139 patients with congenital or acquired heart disease at a single pediatric cardiology center from 1970 to 2024.
Stratified the patient cohort into three severity tiers using the modified World Health Organization classification system to compare clinical worsening, therapeutic interventions, and complication rates.
Clinical-instrumental worsening of maternal heart disease occurred in 8% of the mild group, 32% of the moderate group, and 46% of the severe group.
Severe maternal heart disease was associated with higher rates of intensified cardiac therapy, postpartum intensive care admission, cesarean delivery, abortion, preterm birth, and low birth weight.
Rates of obstetric complications were similar across severity groups, and newborn heart disease recurrence did not correlate with maternal disease severity.

Study Design

Type

Observational (n=139)

Multicenter

Structured PICO

Population

139 pregnant women with congenital or acquired heart disease (accounting for 287 pregnancies) evaluated retrospectively from 1970 to 2024.

Outcome

Clinical-instrumental trends, maternal gestational complications, obstetrical and fetal complications

Main Result

Absolute Event Rate: 46% vs 8%

Cite This Study

synapsesocial.com/papers/6aa9017deed42882c1fc1954 https://doi.org/10.1093/eurheartjsupp/suag058.266

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