Key result
Spinal fluid drainage combined with naloxone significantly protected against paralysis in patients undergoing thoracoabdominal aortic surgery (OR 0.294, p=0.0073).
Why the study?
Do physiological neuroprotective adjuncts such as spinal fluid drainage reduce the risk of paraplegia in patients undergoing thoracoabdominal aortic surgery?
Population
Patients undergoing thoracic and thoracoabdominal aortic surgery. The authors analyzed their own cohort of…
Comparison
Physiological neuroprotective adjuncts… vs Standard surgical techniques without protective…
Design
Review
Authors
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May support spinal fluid drainage with naloxone in thoracoabdominal aortic surgery; leaves open randomized confirmation of neuroprotective strategies.
Do physiological neuroprotective adjuncts such as spinal fluid drainage reduce the risk of paraplegia in patients undergoing thoracoabdominal aortic surgery?
Odds Ratio: 0.294
p-value: p=0.0073
Physiological neuroprotective strategies, particularly spinal fluid drainage and optimizing cardiac index, significantly reduce the risk of paraplegia in thoracoabdominal aortic surgery regardless of the specific surgical technique used.
Acher et al. (2012) conducted a review in Thoracic and thoracoabdominal aortic aneurysms (n=738). Spinal fluid drainage with naloxone vs. No spinal fluid drainage with naloxone was evaluated on Paralysis (OR 0.294, p=0.0073). Spinal fluid drainage combined with naloxone significantly protected against paralysis in patients undergoing thoracoabdominal aortic surgery (OR 0.294, p=0.0073).
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