Key result
Fluid-overloaded chronic dialysis patients had significantly higher plasma alpha-hANP than non-dialysed patients, which decreased significantly to comparable levels after 3-h ultrafiltration.
Why the study?
Does a single 3-hour ultrafiltration reduce plasma alpha-hANP concentrations in fluid-overloaded chronic dialysis patients?
Observational (n=20)
Does a single 3-hour ultrafiltration reduce plasma alpha-hANP concentrations in fluid-overloaded chronic dialysis patients?
Elevated alpha-hANP in chronic uremia is driven by both extracellular fluid expansion (which is reversible by ultrafiltration) and impaired renal clearance.
Basal plasma alpha-human natriuretic peptide (alpha-hANP) values were found to be significantly higher in 7 fluid-overloaded chronic dialysis patients than in 13 non-dialysed renal patients without extracellular fluid (ECF) expansion. Iso-osmotic reduction of the body weight by a single 3-h ultrafiltration caused alpha-hANP to decrease significantly in all anuric patients to values comparable to those of non-dialysed subjects. In this latter group, however, there was a significant inverse relationship between alpha-hANP and glomerular filtration rate but not between alpha-hANP and total blood volume. These findings suggest that both ECF expansion and impaired renal removal of alpha-hANP might be responsible for the high alpha-hANP in chronic uraemia.
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Cannella et al. (1987) conducted an observational in Chronic uraemia (n=20). Fluid overload and ultrafiltration vs. Non-dialysed renal patients without extracellular fluid expansion was evaluated on Plasma alpha-human natriuretic peptide (alpha-hANP) concentrations. Fluid-overloaded chronic dialysis patients had significantly higher plasma alpha-hANP than non-dialysed patients, which decreased significantly to comparable levels after 3-h ultrafiltration.
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