Key result
Extra-corporeal ultrafiltration significantly decreased plasma hANP levels compared to hemodialysis without fluid removal (p<0.01).
Why the study?
Does fluid removal during hemodialysis reduce plasma hANP levels in patients with chronic renal failure?
Does fluid removal during hemodialysis reduce plasma hANP levels in patients with chronic renal failure?
Answers are grounded in this paper and cite their sources.
The reduction in plasma hANP levels during hemodialysis is primarily driven by the reduction in circulating plasma volume rather than osmotic pressure changes.
Plasma immunoreactive human atrial natriuretic peptide (hANP) levels were measured in 9 patients with chronic renal failure treated with maintenance hemodialysis in order to evaluate the effects of fluid removal and osmotic pressure. Under hemodialysis without fluid removal plasma hANP levels remained unchanged, but the levels were significantly decreased during extra-corporeal ultrafiltration (p less than 0.01). The present study provided strong evidence that the fall in plasma hANP levels in hemodialysis patients is mainly due to the reduction in circulating plasma volume.
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Shiota et al. (2008) studied Chronic renal failure (n=9). Extra-corporeal ultrafiltration (fluid removal) vs. Hemodialysis without fluid removal was evaluated on Plasma immunoreactive human atrial natriuretic peptide (hANP) levels (p=<0.01). Extra-corporeal ultrafiltration significantly decreased plasma hANP levels compared to hemodialysis without fluid removal (p<0.01).
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