Key result
Root-mean-square (RMS) fluctuations of cardiac beat-to-beat intervals distinguished sick newborn infants with favourable versus adverse outcomes more consistently and earlier than DFA exponents.
Why the study?
Can detrended fluctuation analysis of cardiac beat-to-beat intervals distinguish between favourable and adverse outcomes in sick newborn infants?
Observational
Can detrended fluctuation analysis of cardiac beat-to-beat intervals distinguish between favourable and adverse outcomes in sick newborn infants?
Answers are grounded in this paper and cite their sources.
Root-mean-square fluctuations of cardiac beat-to-beat intervals may serve as an early and consistent marker to distinguish clinical outcomes in sick newborn infants.
We performed detrended fluctuation analysis (DFA) of cardiac beat-to-beat intervals (RRis) collected from sick newborn infants over 1–4 day periods. We calculated four different metrics from the DFA fluctuation function: the DFA exponents (>40 beats up to one-fourth of the record length), (15–30 beats), root-mean-square (RMS) fluctuation on a short-time scale (20–50 beats), and RMS fluctuation on a long-time scale (110–150 beats). Except , all metrics clearly distinguished two groups of newborn infants (favourable vs. adverse) with well-characterized outcomes. However, the RMS fluctuations distinguished the two groups more consistently over time compared to . Furthermore, RMS distinguished the RRi of the two groups earlier compared to the DFA exponent. In all the three measures, the favourable outcome group displayed higher values, indicating a higher magnitude of (auto-)correlation and variability, thus normal physiology, compared to the adverse outcome group.
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Govindan et al. (2014) conducted an observational in Sick newborn infants. Detrended fluctuation analysis (DFA) of cardiac beat-to-beat intervals vs. Adverse outcome group was evaluated on Distinction between favourable and adverse outcome groups. Root-mean-square (RMS) fluctuations of cardiac beat-to-beat intervals distinguished sick newborn infants with favourable versus adverse outcomes more consistently and earlier than DFA exponents.
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