Key result
Baseline calprotectin was significantly increased (34.05 ± 11.72) and periostin decreased (1.59 ± 0.41) in periodontitis patients with CAD, with parameters improving 180 days post-therapy.
Why the study?
The study evaluated the effect of non-surgical periodontal therapy on periodontal and cardiac parameters and on calprotectin and periostin levels in periodontitis patients with and without coronary artery disease.
Does non-surgical periodontal therapy improve periodontal and cardiac parameters, and alter calprotectin and periostin levels in periodontitis patients with and without coronary artery disease?
Cohort (n=90)
Does non-surgical periodontal therapy improve periodontal and cardiac parameters, and alter calprotectin and periostin levels in periodontitis patients with and without coronary artery disease?
Non-surgical periodontal therapy improves cardiac and periodontal parameters, and gingival crevicular fluid levels of calprotectin and periostin may serve as biomarkers linking periodontitis and coronary artery disease.
NSPT was associated with improved parameters in P+CAD; hypothesis-generating for calprotectin and periostin as linking biomarkers.
OBJECTIVE: The aim of the study was to assess the effect of non-surgical periodontal therapy (NSPT) on periodontal and cardiac parameters as well as on the expression of calprotectin and periostin levels in periodontitis patients with and without coronary artery disease (CAD). METHODS: Ninety subjects were categorised into three groups: Group H: periodontally and systemically healthy subjects, Group P: stage III grade B periodontitis subjects with no associated systemic diseases and Group P + CAD: stage III grade B periodontitis subjects diagnosed with CAD. Demographic, periodontal and cardiac parameters were recorded at baseline (0 day) and on the 180th day after NSPT. Gingival crevicular fluid was collected from all participants at baseline (0 day) and after the 180th day. Calprotectin and periostin expression were reassessed. RESULTS: A significant increase in the levels of calprotectin (34.05 ± 11.72) was seen at baseline in the P + CAD group, whereas on the contrary, a decreased periostin (1.59 ± 0.41) was also noted at baseline. The study also showed a significant improvement in periodontal and cardiac parameters on the 180th day following NSPT. CONCLUSION: Detection of calprotectin and periostin expression in GCF samples could represent a link to the association of periodontitis and CAD.
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Mahendra et al. (2023) conducted a cohort in Periodontitis with and without coronary artery disease (CAD) (n=90). Non-surgical periodontal therapy (NSPT) vs. Baseline / Healthy controls was evaluated on Periodontal and cardiac parameters, calprotectin and periostin levels. Baseline calprotectin was significantly increased (34.05 ± 11.72) and periostin decreased (1.59 ± 0.41) in periodontitis patients with CAD, with parameters improving 180 days post-therapy.
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