Key result
Chronic nonspecific neck pain was associated with significantly reduced heart rate variability, including a 10.24 ms lower SDNN compared to healthy controls.
Why the study?
This study investigates heart rate variability in chronic nonspecific neck pain patients to evaluate HRV as an objective biomarker for comprehensive assessment.
Is chronic nonspecific neck pain associated with reduced heart rate variability compared to healthy controls?
Case-Control (n=160)
No
Is chronic nonspecific neck pain associated with reduced heart rate variability compared to healthy controls?
Chronic nonspecific neck pain is associated with significantly reduced heart rate variability, suggesting autonomic nervous system dysfunction that correlates with pain intensity, anxiety, and cervical instability.
Answers are grounded in this paper and cite their sources.
Chronic neck pain was associated with reduced HRV; leaves open causal direction and clinical relevance pending prospective studies.
BACKGROUND: This study investigates heart rate variability (HRV) in chronic nonspecific neck pain (CNNP) patients, revealing reduced HRV linked to pain intensity, anxiety, and cervical instability, and proposes HRV as an objective biomarker for comprehensive CNNP assessment. METHOD: According to the inclusion and exclusion criteria, 80 patients were included in the experimental group. In addition, 80 healthy individuals matched for age, sex, and other basic information were selected as the control group. The clinical outcome of patients was assessed using the visual analog scale and the self-rating anxiety scale. Subsequently, imaging studies were performed to assess cervical stability (atlantoaxial deviation, axis rotation), osteophytes, physiologic curvature, and disc herniation in patients. The frequency domain (low frequency, high frequency, and their ratio) and time domain (standard deviation of all normal-to-normal QRS intervals) HRV indexes were obtained from all subjects using the heart rate meters. RESULTS: All HRV indexes were significantly lower in patients compared to controls, and pain and anxiety further reduced HRV indexes in patients. Pain intensity, anxiety, and disc herniation were significantly correlated with all the HRV indexes. Mild instability was not correlated with the HRV, but instability reaching a certain level (atlantoaxial deviation >0.1 mm or rotation of the axis >2 mm) was significantly correlated with the HRV indexes. DISCUSSION: Chronic nonspecific neck pain associated with autonomic nervous system dysfunction, and heart rate variability provides an objective and comprehensive assessment of chronic nonspecific neck pain.
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Zhang et al. (2025) conducted a case-control in Chronic nonspecific neck pain (n=160). Chronic nonspecific neck pain vs. Healthy controls was evaluated on Standard deviation of all normal-to-normal beat intervals (SDNN) (MD -10.24, 95% CI -12.03 to -8.45, p=<0.01). Chronic nonspecific neck pain was associated with significantly reduced heart rate variability, including a 10.24 ms lower SDNN compared to healthy controls.
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