Key result
Pedigree analysis of 108 rhesus macaques with pronounced hypertrophic cardiomyopathy revealed a strong genetic predisposition to the disease.
Observational (n=108)
Rhesus macaques demonstrate a strong genetic predisposition to hypertrophic cardiomyopathy, suggesting they are a valuable animal model for investigating the disease due to their genetic and physiological similarities to humans.
Rhesus macaques may model genetic HCM; leaves open validation and human translation.
Background Hypertrophic cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Methods Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed. Results Analyses revealed a strong genetic predisposition to this disease. Conclusions Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.
No takes yet. Share an insight, caveat, or question.
Kanthaswamy et al. (2014) conducted an observational in Hypertrophic cardiomyopathy (HCM) (n=108). Genetic predisposition was evaluated on Genetic predisposition to HCM. Pedigree analysis of 108 rhesus macaques with pronounced hypertrophic cardiomyopathy revealed a strong genetic predisposition to the disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: