Key result
During competitive flow, ITA total flow was reduced to 8.2 ml/min compared to 10.0 ml/min in SVG (P<0.005), with ITA diastolic flow reduced by 80.7% and exhibiting early systolic retrograde flow.
Why the study?
Does ITA grafting compared to SVG grafting result in different pressure and flow dynamics during competitive flow in a canine model?
Population
10 mongrel dogs undergoing saphenous vein graft and internal thoracic artery to proximal left anterior…
Comparison
Internal thoracic artery (ITA) graft vs Saphenous vein graft (SVG)
Design
Preclinical
Authors
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ITA grafts exhibit greater flow impairment than SVG during competitive flow in canines; leaves open relevance to human graft failure mechanisms.
Does ITA grafting compared to SVG grafting result in different pressure and flow dynamics during competitive flow in a canine model?
Absolute Event Rate: 8.2% vs 10%
p-value: p=<0.005
In a canine model, competitive flow causes more severe flow reduction and systolic retrograde flow in ITA grafts compared to SVG grafts, which may explain ITA graft failure in the presence of patent native vessels.
Sebastian Pagni (1997) studied Competitive flow in coronary bypass grafts (n=10). Internal thoracic artery (ITA) graft vs. Saphenous vein graft (SVG) was evaluated on Total flow during competitive flow (ml/min) (p=<0.005). During competitive flow, ITA total flow was reduced to 8.2 ml/min compared to 10.0 ml/min in SVG (P<0.005), with ITA diastolic flow reduced by 80.7% and exhibiting early systolic retrograde flow.
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