Key result
Oral administration of doxorubicin in rats resulted in approximately 1% bioavailability, primarily due to limited paracellular intestinal absorption rather than first-pass metabolism or efflux.
Why the study?
Does limited intestinal absorption via the paracellular pathway explain the low oral bioavailability of doxorubicin in rats and Caco-2 cells?
Population
Rats and Caco-2 cell monolayers
Design
Preclinical
Authors
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Should not alter clinical doxorubicin use; extends preclinical absorption insights but remains hypothesis-generating for human translation.
Does limited intestinal absorption via the paracellular pathway explain the low oral bioavailability of doxorubicin in rats and Caco-2 cells?
The low oral bioavailability of doxorubicin is primarily driven by limited intestinal absorption via the paracellular pathway rather than first-pass metabolism or efflux pumps.
Kim et al. (2012) studied this question. Doxorubicin was evaluated on Oral bioavailability and intestinal absorption. Oral administration of doxorubicin in rats resulted in approximately 1% bioavailability, primarily due to limited paracellular intestinal absorption rather than first-pass metabolism or efflux.
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