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November 1, 1998Journal of Clinical Oncology

Epirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancer.

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Why the study?

Does the cumulative dose of epirubicin increase the risk of congestive heart failure in anthracycline-naive patients with metastatic breast cancer?

Population

469 consecutive anthracycline-naive patients with metastatic breast cancer

Design

Cohort

Authors

MRM. RybergFrederiksberg HospitalDNDorte NielsenUniversity of CopenhagenTSTorben SkovsgaardUniversity of Copenhagen

Discussion

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Implication

May support limiting epirubicin to 900 mg/m2; leaves open confirmation in randomized trials.

Structured PICO

Does the cumulative dose of epirubicin increase the risk of congestive heart failure in anthracycline-naive patients with metastatic breast cancer?

P
Population
469 consecutive anthracycline-naive patients with metastatic breast cancer
I
Intervention
Epirubicin
O
Outcome
Congestive heart failure (CHF) according to New York Heart Association (NYHA) function class II or moresafety

The risk of epirubicin-induced congestive heart failure increases significantly at cumulative doses >950 mg/m2, supporting a recommended maximum cumulative dose of 900 mg/m2.

Cite This Study

Ryberg et al. (1998) studied this question.

synapsesocial.com/papers/6a709d615671bbf00bc2bccdhttps://doi.org/10.1200/jco.1998.16.11.3502

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac morphologic and functional changes induced by epirubicin chemotherapy.1989 · 46 citations
  2. 2Epirubicin cardiotoxicity: a study of 135 patients with advanced breast cancer.1990 · 100 citations
  3. 3A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer.1985 · 251 citations
  4. 4Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue.1986 · 301 citations
  5. 5Doxorubicin-induced congestive heart failure in adults1985 · 125 citations