Key result
Vaccination with the YL6 inactivated vaccine combined with XZB provided 100% protection (0% mortality) against challenge with virulent nephropathogenic infectious bronchitis virus, compared to 100% mortality in unvaccinated controls.
Why the study?
Does combined immunization with XZB and YL6 vaccines prevent infection and mortality from nephropathogenic avian infectious bronchitis virus in chickens?
Does combined immunization with XZB and YL6 vaccines prevent infection and mortality from nephropathogenic avian infectious bronchitis virus in chickens?
Absolute Event Rate: 0% vs 100%
An inactivated vaccine based on the recent field strain YL6 combined with a commercial live vaccine provided excellent protection against nephropathogenic avian infectious bronchitis virus in chickens.
May inform poultry vaccine development against nephropathogenic IBV; leaves open field efficacy and commercial translation.
BACKGROUND: In last three years, 96 suspected poultry farms from different provinces in China were diagnosed for avian infectious bronchitis (IB) survey. Finally, 221 IBV strains were confirmed by dwarf embryo test and RT-PCR assay. By virus recovery trials, 187 of the isolates caused the birds died or distressed from nephritis, which was accordant with the clinical record. RESULTS: Based on epidemiology analysis of recent field isolates of nephropathogenic IB in vaccinated farms in China, YL6 strain were used for vaccination and evaluated by antibody titer and challenge tests. The immunoprotection test indicated that the practical application of vaccine based on the recent field strains could finely facilitate controlling the nephropathogenic IB. CONCLUSIONS: Our study was aim at setting a guide for safeguard against nephropathogenic IBV-caused disease in China.
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Xie et al. (2011) studied Avian infectious bronchitis (n=80). YL6 inactivated oil-emulsion vaccine vs. Unvaccinated (PBS) was evaluated on Death rate after challenge with virulent nephropathogenic HY51 strain. Vaccination with the YL6 inactivated vaccine combined with XZB provided 100% protection (0% mortality) against challenge with virulent nephropathogenic infectious bronchitis virus, compared to 100% mortality in unvaccinated controls.
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