Key result
A history of deep vein thrombosis in patients with type 2 diabetes was associated with a significantly increased risk of major adverse limb events (8.4% vs. 5.2%; SHR 1.60).
Why the study?
Little is known about the association between deep vein thrombosis and arterial complications in patients with type 2 diabetes.
Does a history of deep vein thrombosis increase the risk of major adverse limb events in patients with type 2 diabetes?
Population
1,628,675 patients with T2DM in Taiwan
Comparison
Patients with prior DVT vs without DVT
Design
Nationwide retrospective cohort study
Follow-up
Mean 5.2 years
Authors
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Prior DVT was associated with higher MALE risk in T2D; leaves open whether targeted prevention or surveillance improves limb outcomes.
Cohort (n=1,628,675)
Does a history of deep vein thrombosis increase the risk of major adverse limb events in patients with type 2 diabetes?
Hazard Ratio: 1.6 (95% CI 1.34–1.9)
Absolute Event Rate: 8.4% vs 5.2%
A history of deep vein thrombosis in patients with type 2 diabetes is independently associated with a significantly increased risk of major adverse limb events, major amputation, and mortality.
Wang et al. (2021) conducted a cohort in Type 2 diabetes (n=1,628,675). Deep vein thrombosis vs. No history of deep vein thrombosis was evaluated on Major adverse limb events (MALEs) (SHR 1.60, 95% CI 1.34-1.90). A history of deep vein thrombosis in patients with type 2 diabetes was associated with a significantly increased risk of major adverse limb events (8.4% vs. 5.2%; SHR 1.60).
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