Key result
Elevated neutrophils-to-lymphocytes ratio was significantly higher in children with acute heart failure compared to controls and appears to be a predictor of short-term mortality.
Why the study?
Heart failure is a common cause of morbidity and mortality in pediatric patients, prompting evaluation of whether the neutrophil-to-lymphocyte ratio helps predict mortality and adverse outcomes.
Does an elevated Neutrophils-to-Lymphocytes Ratio (NLR) predict short-term mortality and adverse outcomes in children with acute heart failure?
Observational (n=80)
No
Does an elevated Neutrophils-to-Lymphocytes Ratio (NLR) predict short-term mortality and adverse outcomes in children with acute heart failure?
Elevated neutrophils-to-lymphocytes ratio (NLR) is significantly associated with acute heart failure in pediatric patients with congenital heart disease and may serve as a predictor of short-term mortality.
May support NLR for short-term risk stratification in pediatric acute HF; hypothesis-generating and requires prospective validation before clinical use.
Background: Heart failure is a common cause of morbidity and mortality in pediatric patients in the third world. Heart failure in children occurs due to heart lesions that cause volume overload as in large ventricular septal defect or due to lesions that causes obstruction to flow as in aortic stenosis. Objective: This study aimed to evaluate the neutrophils to lymphocytes ratio in children with heart failure & to investigate if this ratio is helpful in predicting mortality and adverse outcome in those patients. Patients and methods: Our study was performed over a number of 80 children 40 of them were having CHD with acute heart failure, 20 of them were congenital heart disease (CHD) without failure and 20 of them were normal. The was conducted in Pediatric Cardiology Unit and Pediatric ICU, Zagazig University Children Hospitals during the period from February 2017 till May 2018. Results: Our present work showed that neutrophils, CRP and NLR were statistically higher in the Heart failure group compared to cardiac group and control group. While lymphocytes and oxygen saturation (SO2) were statistically lower in the heart failure group. The echocardiographic findings showed that compared to cardiac group, the heart failure group was significantly higher regarding PAP and LVEDD but significantly lower regarding EF and FS. Conclusion: Elevated NLR seems to be a predictor of short-term mortality in patients with acute heart failure.
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Ibrahim et al. (2020) conducted an observational in Acute Heart Failure in Children (n=80). Elevated neutrophils-to-lymphocytes ratio (NLR) vs. Normal or lower neutrophils-to-lymphocytes ratio was evaluated on Short-term mortality and adverse outcomes. Elevated neutrophils-to-lymphocytes ratio was significantly higher in children with acute heart failure compared to controls and appears to be a predictor of short-term mortality.
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