Key result
In the isolated rabbit heart, GBR 12909 accumulated in the myocardium and produced concentration-dependent biphasic negative inotropic and chronotropic effects.
Population
Isolated rabbit heart model
Comparison
GBR 12909 (concentration range 0.01 to 12400 nM) vs Control level
Design
Preclinical
Authors
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Warrants caution in GBR 12909 development; leaves open translation from isolated rabbit heart to clinical effects.
In an isolated rabbit heart model, the dopamine reuptake inhibitor GBR 12909 demonstrated significant myocardial accumulation and membrane-stabilizing properties, resulting in negative inotropic, chronotropic, and dromotropic effects.
Nielsen‐Kudsk et al. (1990) studied Isolated rabbit heart. GBR 12909 vs. control level was evaluated on Myocardial accumulation kinetics and pharmacodynamics. In the isolated rabbit heart, GBR 12909 accumulated in the myocardium and produced concentration-dependent biphasic negative inotropic and chronotropic effects.
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