Population
Isolated, perfused rabbit hearts
Design
Preclinical
Authors
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Should not change clinical TCA use; leaves open human relevance at therapeutic doses.
Supratherapeutic concentrations of tricyclic antidepressants amitriptyline and clomipramine exert significant negative inotropic effects and conduction delays in an isolated rabbit heart model.
Nielsen‐Kudsk et al. (1980) studied this question.
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