January 1, 1982Journal of Toxicology Clinical Toxicology

Protective Effects of Clonidine and Verapamil in Experimental Amitriptyline Poisoning in Rabbits

View Full Paper

Ask AI

Bookmark

Why the study?

Do clonidine and verapamil reduce cardiotoxicity in rabbits with acute amitriptyline poisoning?

Population

Conscious rabbits with acute amitriptyline-induced cardiotoxicity (amitriptyline 50 mg/kg, IP)

Design

Preclinical

Authors

AEAntoine El-HageUnited States Food and Drug Administration TBTibor BalázsSlovak Medical University WWWilliam L. WestHoward University

Discussion

Member takes

Implication

May support further preclinical testing in amitriptyline toxicity; leaves open translation to human clinical practice.

Structured PICO

Do clonidine and verapamil reduce cardiotoxicity in rabbits with acute amitriptyline poisoning?

Population

Conscious rabbits with acute amitriptyline-induced cardiotoxicity (amitriptyline 50 mg/kg, IP)

Intervention

Clonidine (50 micrograms/kg, IV) and verapamil (0.25 mg/kg, IV) alone or in combination at lower doses (25 micrograms/kg plus 0.125 mg/kg, respectively)

Outcome

Electrocardiographic changes (Q-T intervals, QRS complex), arrhythmias, convulsion, hypotension, and protection against a lethal dose of amitriptyline (75 mg/kg)surrogate

Clonidine and verapamil show promise as antidotal agents for acute amitriptyline-induced cardiotoxicity in an experimental rabbit model.

Cite This Study

El-Hage et al. (1982) studied this question.

synapsesocial.com/papers/6a725bae439bab0cabc3d3de https://doi.org/10.3109/15563658209025738

View Full Paper

Ask AI

Bookmark

Protective Effects of Clonidine and Verapamil in Experimental Amitriptyline Poisoning in Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protective Effects of Clonidine and Verapamil in Experimental Amitriptyline Poisoning in Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider