January 1, 1984Journal of Cardiovascular Pharmacology
Experimental Amitriptyline Intoxication
Key result
Sodium bicarbonate rapidly reverses amitriptyline-induced ventricular tachyarrhythmias in ~100% of treated dogs.
- n=12
Why the study?
Does sodium bicarbonate reverse amitriptyline-induced ventricular tachyarrhythmias in a canine model?
Population
12 dogs (6 awake, 6 anesthetized)
Design
Preclinical
Authors
Discussion
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Implication
Supports bicarbonate in canine amitriptyline tachyarrhythmias; leaves open translation to human toxicity management.
Structured PICO
Does sodium bicarbonate reverse amitriptyline-induced ventricular tachyarrhythmias in a canine model?
P
Population
12 dogs (6 awake and 6 anesthetized) subjected to experimental amitriptyline infusion to evaluate cardiac effects and treatments.
I
Intervention
Amitriptyline infusion, followed by sodium bicarbonate for animals developing ventricular tachyarrhythmias
O
Outcome
Cardiac effects including heart rate, QRS duration, AH and HV intervals, and occurrence/reversal of ventricular tachyarrhythmiassurrogate
Sodium bicarbonate is an effective therapy for reversing amitriptyline-induced ventricular arrhythmias in a canine model.
Cite This Study
Nattel et al. (1984) studied Amitriptyline intoxication (n=12). Amitriptyline infusion was evaluated on Development of ventricular tachyarrhythmias and cardiac conduction changes. Amitriptyline infusion induced ventricular tachyarrhythmias in 11 of 12 dogs, which were rapidly reversed by sodium bicarbonate administration in all 7 treated animals.