Key result
Administration of high doses of amitriptyline as a sustained release preparation caused fewer toxic manifestations and electrocardiographic changes than conventional tablets in cats and dogs.
Why the study?
Does high-dose amitriptyline given as a sustained release preparation reduce electrocardiographic and cardiovascular toxicity compared to conventional tablets in cats and dogs?
Population
Anesthetized cats and conscious dogs
Comparison
High doses of amitriptyline given as a sustained… vs High doses of amitriptyline given as…
Design
Preclinical
Authors
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Hypothesis-generating in animal models; leaves open whether sustained-release formulations reduce human amitriptyline toxicity.
Does high-dose amitriptyline given as a sustained release preparation reduce electrocardiographic and cardiovascular toxicity compared to conventional tablets in cats and dogs?
Sustained release amitriptyline produces fewer electrocardiographic and clinical toxicities than conventional tablets in animal models, primarily due to slower absorption.
Boeck et al. (1980) studied Amitriptyline toxicity. Sustained release amitriptyline vs. Conventional amitriptyline tablets was evaluated on Electrocardiographic and haemodynamic changes. Administration of high doses of amitriptyline as a sustained release preparation caused fewer toxic manifestations and electrocardiographic changes than conventional tablets in cats and dogs.
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