Population
Isolated perfused hearts from 30 outbred albino rats
Design
Preclinical
Authors
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May warrant caution with amitriptyline in cardiac patients; leaves open translation from isolated rat heart models to clinical settings.
In an isolated rat heart model, amitriptyline demonstrated direct cardiotoxicity by depressing myocardial contractility and causing cellular damage.
Чекмарев et al. (2011) studied this question.
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