What question did this study set out to answer?

To investigate whether theophylline administration can reverse cardiovascular toxicity and conduction abnormalities induced by amitriptyline overdose in an anesthetized rat model.

October 18, 2010Drug and Chemical Toxicology

An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline

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Why the study?

Does theophylline improve cardiovascular parameters in a rat model of amitriptyline toxicity?

Population

Anaesthetized rat model of amitriptyline toxicity

Comparison

Theophylline 1 mg/kg bolus followed by 0.5-mg/kg… vs 5% dextrose bolus followed by 5% dextrose infusion

Design

Preclinical, Randomized to two groups

Authors

KOKubilay OransayDokuz Eylül University ŞKŞule KalkanDokuz Eylül University NHNil HocaoğluDokuz Eylül University

Discussion

Member takes

Implication

Theophylline may merit further preclinical testing in amitriptyline toxicity; leaves open translation to human overdose management.

Key Points

To investigate whether theophylline administration can reverse cardiovascular toxicity and conduction abnormalities induced by amitriptyline overdose in an anesthetized rat model.
Amitriptyline was infused at 0.94 mg/kg/min into anesthetized rats until mean arterial pressure (MAP) decreased by 40–45%.
Rats were randomized to receive either control treatment (5% dextrose bolus followed by infusion) or theophylline (1 mg/kg bolus followed by a 0.5 mg/kg infusion).
Theophylline administration significantly increased mean arterial pressure, shortened amitriptyline-induced QRS prolongation, and elevated heart rate compared with dextrose control (P < 0.05 for all).
No statistically significant differences were observed in arterial blood-gas parameters between the theophylline and dextrose groups (P > 0.05).

Structured PICO

Does theophylline improve cardiovascular parameters in a rat model of amitriptyline toxicity?

Population

Anaesthetized rat model of amitriptyline toxicity (induced by infusion of 0.94 mg/kg/min of amitriptyline up to 40-45% inhibition of mean arterial pressure)

Intervention

Theophylline 1 mg/kg bolus followed by 0.5-mg/kg infusion

Comparator

5% dextrose bolus followed by 5% dextrose infusion

Outcome

Mean arterial pressure (MAP), QRS duration, and heart rate (HR)surrogate

Theophylline effectively reversed hypotension and QRS prolongation in a rat model of amitriptyline toxicity, possibly via nonselective adenosine antagonism.

Cite This Study

Oransay et al. (2010) studied this question.

synapsesocial.com/papers/6a828c18c40fc255ce1330ee https://doi.org/10.3109/01480545.2010.495947

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An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider