What is the clinical evidence from this study?

Study design: Other. Population: Amitriptyline-induced cardiovascular toxicity. Intervention: EHNA and NBTI pretreatment vs. 5% dextrose pretreatment. Primary outcome: Mean arterial pressure, heart rate, QT and QRS durations, and plasma adenosine concentrations.

December 14, 2011Drug and Chemical Toxicology

Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats

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Key result

Pretreatment with adenosine transport and deaminase inhibitors augmented amitriptyline-induced cardiovascular toxicity in rats.

Authors

ŞKŞule KalkanDokuz Eylül University NHNil HocaoğluDokuz Eylül University KOKubilay OransayDokuz Eylül University

Discussion

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Implication

Adenosine modulation may influence amitriptyline cardiotoxicity; leaves open translation to human TCA overdose management.

PICO

Population

Rats subjected to amitriptyline infusion to study the contribution of endogenous adenosine to cardiovascular toxicity.

Intervention / Comparator

EHNA and NBTI pretreatment vs 5% dextrose pretreatment (EHNA 10 mg/kg i.p. and NBTI 1 mg/kg i.p.)

Primary Outcome

Mean arterial pressure, heart rate, QT and QRS durations, and plasma adenosine concentrations

Cite This Study

Kalkan et al. (2011) studied Amitriptyline-induced cardiovascular toxicity. EHNA and NBTI pretreatment vs. 5% dextrose pretreatment was evaluated on Mean arterial pressure, heart rate, QT and QRS durations, and plasma adenosine concentrations. Pretreatment with adenosine transport and deaminase inhibitors augmented amitriptyline-induced cardiovascular toxicity in rats.

synapsesocial.com/papers/6a22bb2665451dc9090e286b https://doi.org/10.3109/01480545.2011.640682

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Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats

Discussion

Member takes

Implication

PICO

Cite This Study

Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider