Why the study?
Does pretreatment with adenosine receptor antagonists improve amitriptyline-induced QRS prolongation in isolated rat hearts?
Population
Isolated rat hearts with amitriptyline-induced QRS prolongation
Comparison
Pretreatment with selective adenosine A1… vs Control groups receiving amitriptyline alone
Design
Preclinical
Follow-up
up to 60 minutes
Authors
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Should not yet change practice in amitriptyline toxicity; hypothesis-generating for A1 antagonism in isolated rat hearts.
Does pretreatment with adenosine receptor antagonists improve amitriptyline-induced QRS prolongation in isolated rat hearts?
In an isolated rat heart model, the adenosine A1 receptor antagonist DPCPX shortened amitriptyline-induced QRS prolongation, whereas the A2a receptor antagonist CSC prolonged it.
Akgun et al. (2008) studied this question.
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