Key result
The fall in calcium for a given fall in albumin after myocardial infarction did not differ significantly between patients, validating the use of a single adjustment equation in disease states.
Why the study?
Does the relationship between plasma calcium and albumin changes differ after venous stasis compared to myocardial infarction?
Observational
Does the relationship between plasma calcium and albumin changes differ after venous stasis compared to myocardial infarction?
The adjustment of calcium for albumin using a single equation remains valid in patients with changes in albumin due to disease such as myocardial infarction, but blood should be drawn with minimal venous stasis.
Answers are grounded in this paper and cite their sources.
Supports single-equation calcium adjustment post-MI; leaves open whether venous stasis alters the relationship.
Others have challenged the concept of adjusting total plasma calcium for albumin concentration on the grounds that after the application of a tourniquet the increase in calcium for a given increase in albumin differs significantly between normal individuals. We have confirmed this finding. In contrast, we have found that after myocardial infarction the fall in calcium for a given fall in albumin does not differ significantly between patients. Thus the adjustment of calcium for albumin using a single equation remains valid in patients with changes in albumin due to disease. We recommend that for consistent results blood should be taken with the minimum of venous stasis even though the patient's calcium is to be adjusted for albumin.
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Walker et al. (1979) conducted an observational in Myocardial infarction. Changes in plasma albumin after venous stasis or myocardial infarction was evaluated on Change in plasma total calcium for a given change in albumin. The fall in calcium for a given fall in albumin after myocardial infarction did not differ significantly between patients, validating the use of a single adjustment equation in disease states.
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