Key result
In patients undergoing off-pump coronary artery bypass surgery, 6% HES 130/0.4 significantly reduced postoperative chest tube drainage (665 vs 919 ml) and packed red blood cell transfusion requirements compared to 6% HES 200/0.5.
Why the study?
Does 6% HES 130/0.4 reduce postoperative bleeding and maintain tissue oxygenation compared to 6% HES 200/0.5 in patients undergoing off-pump coronary artery bypass surgery?
Population
44 patients undergoing off-pump coronary artery bypass surgery (OPCAB)
Comparison
6% Hydroxyethyl Starch 130/0.4 infused for fluid… vs 6% Hydroxyethyl Starch 200/0.5 infused for fluid…
Design
Cohort
Follow-up
16 hours after surgery
Authors
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May reduce bleeding/transfusions in off-pump CABG; hypothesis-generating and should not yet change practice pending RCTs.
RCT (n=39)
Open-label
Randomized
No
Does 6% HES 130/0.4 reduce postoperative bleeding and maintain tissue oxygenation compared to 6% HES 200/0.5 in patients undergoing off-pump coronary artery bypass surgery?
Absolute Event Rate: 665% vs 919%
p-value: p=0.027
In patients undergoing off-pump CABG, 6% HES 130/0.4 reduces postoperative bleeding and transfusion requirements compared to 6% HES 200/0.5 without compromising tissue oxygenation or hemodynamics.
Kim et al. (2007) conducted an RCT in Off-pump coronary artery bypass surgery (OPCAB) (n=39). 6% Hydroxyethyl starch (HES) 130/0.4 vs. 6% HES 200/0.5 was evaluated on Postoperative chest tube drainage (p=0.027). In patients undergoing off-pump coronary artery bypass surgery, 6% HES 130/0.4 significantly reduced postoperative chest tube drainage (665 vs 919 ml) and packed red blood cell transfusion requirements compared to 6% HES 200/0.5.
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