Key result
Low power helium-neon laser irradiation protected human erythrocytes from damage in an in vitro artificial heart-lung machine model, significantly improving deformability and ATP levels.
Why the study?
Does low power helium-neon laser irradiation protect human erythrocytes from damage in an artificial heart-lung machine model?
Does low power helium-neon laser irradiation protect human erythrocytes from damage in an artificial heart-lung machine model?
Low power He-Ne laser irradiation protects human erythrocytes from mechanical damage during extracorporeal circulation in an in vitro model.
Hypothesis-generating for erythrocyte protection in extracorporeal circuits; clinical translation requires prospective in vivo validation.
The protective effect of the low power helium-neon (He-Ne) laser against the damage of human erythrocytes in whole blood was examined in a perfusion model using an artificial heart-lung machine. Preserved human whole blood was diluted and perfused in 2 closed circuits with a double roller pump. The laser irradiated one of the circuits (laser group), and none the other (control group). In the laser group, erythrocyte deformability and erythrocyte adenosine triphosphate (ATP) levels were significantly higher, and free hemoglobin levels were significantly lower than those in the control group. Subsequent morphological findings by means of scanning electron microscope were consistent with these results. Low power He-Ne laser protected human erythrocytes in the preserved diluted whole blood from the damage caused by experimental artificial heart-lung machines. The clinical application of low power laser treatment for extracorporeal circulation is suggested.
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Itoh et al. (2000) studied Erythrocyte damage during extracorporeal circulation. Low power helium-neon (He-Ne) laser vs. No laser irradiation was evaluated on Erythrocyte deformability, erythrocyte adenosine triphosphate (ATP) levels, and free hemoglobin levels. Low power helium-neon laser irradiation protected human erythrocytes from damage in an in vitro artificial heart-lung machine model, significantly improving deformability and ATP levels.
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