Key result
SSRI therapy for one and six months significantly improved heart rate variability and heart rate turbulence parameters in patients with major depressive disorder (p < 0.001).
Why the study?
Autonomic nervous system dysfunction is associated with depression, but whether HRV and HRT alterations in major depressive disorder normalize or improve under SSRI therapy in parallel with symptom reduction was not clear.
Does SSRI therapy improve heart rate variability and heart rate turbulence in patients with new onset major depressive disorder?
Population
78 patients aged under 51 years with new onset major depressive disorder
Comparison
Before vs after SSRI therapy
Authors
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May support autonomic gains with SSRIs in depression; leaves open effects on cardiovascular events.
Observational (n=78)
No
Does SSRI therapy improve heart rate variability and heart rate turbulence in patients with new onset major depressive disorder?
p-value: p=<0.001
SSRI therapy in patients with new-onset major depressive disorder is associated with significant improvements in autonomic function markers (HRV and HRT) that parallel the reduction in depressive symptoms.
Giurgi-Oncu et al. (2020) conducted an observational in Major depressive disorder (MDD) (n=78). Selective serotonin reuptake inhibitor (SSRI) therapy vs. Baseline (before therapy) was evaluated on Improvement of heart rate variability (HRV) and heart rate turbulence (HRT) parameters (p=<0.001). SSRI therapy for one and six months significantly improved heart rate variability and heart rate turbulence parameters in patients with major depressive disorder (p < 0.001).
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