Key result
Genome-wide linkage analysis identified significant quantitative trait loci for systolic blood pressure on chromosome 12 (LOD 3.5) and cardiac output on chromosome 1 (LOD 3.1) during mental stress.
Why the study?
Does mental and physical stress reveal genetic loci linked to blood pressure and hemodynamic parameters in an Omani Arab population?
Observational (n=1,277)
No
Does mental and physical stress reveal genetic loci linked to blood pressure and hemodynamic parameters in an Omani Arab population?
Effect estimate: LOD 3.5
Mental and physical stress testing in a homogeneous Arab population revealed significant genetic loci for blood pressure and cardiac output on chromosomes 1 and 12, suggesting stress phenotypes may help identify genes involved in essential hypertension.
Stress phenotypes may aid hypertension gene discovery; leaves open replication and clinical translation.
BACKGROUND: We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests. METHODS: The Oman Family Study subjects (N = 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR. RESULTS: Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For △WCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For △CPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. CONCLUSION: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.
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Hassan et al. (2011) conducted an observational in Blood pressure and hemodynamic phenotypes (n=1,277). Mental and physical stress tests (Word Conflict Test and Cold Pressor Test) vs. Resting state was evaluated on Quantitative trait loci (QTLs) linked to systolic blood pressure during mental stress (Word Conflict Test) (LOD 3.5). Genome-wide linkage analysis identified significant quantitative trait loci for systolic blood pressure on chromosome 12 (LOD 3.5) and cardiac output on chromosome 1 (LOD 3.1) during mental stress.
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