Key result
In a homogeneous Arab population, resting and challenged cardiovascular phenotypes were significantly influenced by additive genetic effects, with heritability estimates for stress reactivity ranging from 0.08 to 0.40.
Why the study?
Does acute laboratory stress reveal heritable hemodynamic reactivity in a homogeneous Arab population?
Population
1,277 individuals from five highly consanguineous isolated Arab pedigrees in Oman, mean age 33.5 years…
Comparison
Acute laboratory stressors vs Resting state
Design
Cross-sectional
Authors
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Suggests genetic basis for stress reactivity in Arabs; leaves open replication and hypertension gene discovery.
Observational (n=1,277)
Does acute laboratory stress reveal heritable hemodynamic reactivity in a homogeneous Arab population?
Effect estimate: h2 0.002-0.40 for WCT and 0.08-0.35 for CPT
p-value: p=<0.05
Resting and stress-challenged cardiovascular phenotypes are significantly influenced by additive genetic effects in this homogeneous Arab population, offering potential pathways for gene discovery in hypertension.
Hassan et al. (2009) conducted an observational in Healthy volunteers (n=1,277). Laboratory stressors (Word Conflict Test and Cold Pressor Test) vs. Resting state was evaluated on Heritability estimates (h2) of hemodynamic reactivity to acute stress (h2 0.002-0.40 for WCT and 0.08-0.35 for CPT, p=<0.05). In a homogeneous Arab population, resting and challenged cardiovascular phenotypes were significantly influenced by additive genetic effects, with heritability estimates for stress reactivity ranging from 0.08 to 0.40.
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