A randomized study of the duration of ulnar nerve blockade induced with 2% prilocaine or 0.5% bupivacaine with and without 0.4% hyaluronic acid was performed in volunteers. In contrast to results in experimental animals, the addition of hyaluronic acid to the local anaesthetic solution did not affect the duration of sensory nerve block.
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Johansson et al. (1985) studied this question.
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