The duration of rat infraorbital nerve block by 1% lidocaine or 0.25% bupivacaine, and its modification by low molecular weight dextran, was investigated in a randomized, observer-blind study. The addition of low molecular weight dextran did not prolong the duration of the blocks. No evidence of slow releasing or local anesthetic binding properties attributed to low molecular weight dextran was found.
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Buckley et al. (1981) studied this question.