Key result
Prior exposure to a 40-minute shear rate intervention via forearm heating significantly increased exercise-induced brachial artery vasodilation compared to baseline (4.3 vs 4.1 mm, P<0.05).
Why the study?
Does prior exposure to anterograde shear rate via forearm heating improve exercise-induced brachial artery dilation and blood flow in men?
Does prior exposure to anterograde shear rate via forearm heating improve exercise-induced brachial artery dilation and blood flow in men?
Absolute Event Rate: 4.3% vs 4.1%
p-value: p=<0.05
Prior exposure to anterograde shear rate increases vascular responses to exercise, supporting the potential beneficial effects of anterograde shear rate in vivo.
May support shear-based vascular preconditioning in exercise; hypothesis-generating and should not yet change practice.
Shear rate can elicit substantial adaptations to vascular endothelial function. Recent studies indicate that prior exposure to anterograde flow and shear increases endothelium-dependent flow-mediated dilation at rest and that anterograde shear can create an anti-atherosclerotic and provasodilatory state. The primary aim of the present study was therefore to determine the effects of prior exposure to anterograde shear on exercise-induced brachial artery dilation, total forearm blood flow (FBF), and vascular conductance (FVC) during dynamic handgrip exercise. Eight men completed a constant-load exercise test corresponding to 10% maximal voluntary contraction, prior to (baseline) and following a 40 min shear rate intervention (post-SRI) achieved via unilateral forearm heating, which has previously been shown to increase anterograde shear rate in the brachial artery. During the SRI, anterograde shear rate increased 60.9 ± 29.2 sec(-1) above baseline (P < 0.05). Post-SRI, the exercise-induced brachial artery vasodilation was significantly increased compared to baseline (4.1 ± 0.7 vs. 4.3 ± 0.6 mm, P < 0.05). Post-SRI FBF mean response time (33.2 ± 16.0 vs. 23.0 ± 11.8 sec, P < 0.05) and FVC mean response time (31.1 ± 12.8 20.2 ± 10.7 sec, P < 0.05) at exercise onset were accelerated compared to baseline. These findings demonstrate that prior exposure to anterograde shear rate increases the vascular responses to exercise and supports the possible beneficial effects of anterograde shear rate in vivo.
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Ade et al. (2015) studied this question. Shear rate intervention via unilateral forearm heating vs. Baseline was evaluated on Exercise-induced brachial artery vasodilation (p=<0.05). Prior exposure to a 40-minute shear rate intervention via forearm heating significantly increased exercise-induced brachial artery vasodilation compared to baseline (4.3 vs 4.1 mm, P<0.05).
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