What is the clinical evidence from this study?

Study design: Review. Population: Heart failure with cardiac dyssynchrony. Intervention: Systematic CRT device optimization vs. Standard clinical practice or nominal settings.

August 31, 2014Open Access

Clinical Relevance Of Systematic CRT Device Optimization.

View Full Paper

Ask AI

Bookmark

Key result

Systematic device-based optimization of cardiac resynchronization therapy settings shows potential to improve clinical response rates compared to standard practice, though large prospective trials are ongoing.

Why the study?

Does device-based systematic CRT optimization improve clinical outcomes in advanced heart failure patients with cardiac dyssynchrony?

Population

Advanced heart failure patients with cardiac dyssynchrony receiving Cardiac Resynchronization Therapy (CRT)

Comparison

Device-based CRT settings optimization techniques vs Routine clinical practice or…

Design

Review

Authors

MLMaurizio LunatiElectrophysiology GMG. MagentaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico GCGiuseppe CattafiAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Discussion

Member takes

Implication

May support device-based CRT optimization as echo alternative; leaves open outcome benefits pending prospective trials.

Structured PICO

Does device-based systematic CRT optimization improve clinical outcomes in advanced heart failure patients with cardiac dyssynchrony?

Population

A review of clinical trials evaluating device-based and echocardiographic optimization techniques for patients receiving cardiac resynchronization therapy for advanced heart failure.

Intervention

Device-based CRT settings optimization techniques (including IEGM-based algorithms and hemodynamic/SonR-based automatic algorithms)

Comparator

Routine clinical practice or echocardiography-guided optimization

Outcome

Clinical response (Packer's clinical combined endpoint including all-cause death, heart failure events, NYHA functional class, and Quality of Life)composite

Automatic, device-based hemodynamic optimization of CRT settings offers a practical alternative to echocardiography and may improve long-term clinical response in heart failure patients.

Limitations

Echocardiography optimization is time- and resource-consuming with limited reproducibility.
Retrospective nature of some supporting analyses for frequent optimization.
Short-term follow-up in several of the reviewed trials.
Short-term follow-up in some reviewed trials
Retrospective nature of data comparisons in post-hoc analyses
Modest sample sizes in pilot studies

Cite This Study

Lunati et al. (2014) conducted a review in Heart failure with cardiac dyssynchrony. Systematic CRT device optimization vs. Standard clinical practice or nominal settings was evaluated. Systematic device-based optimization of cardiac resynchronization therapy settings shows potential to improve clinical response rates compared to standard practice, though large prospective trials are ongoing.

synapsesocial.com/papers/6a9b54992e0551cedd882917 https://doi.org/10.4022/jafib.1077

View Full Paper

Ask AI

Bookmark

Clinical Relevance Of Systematic CRT Device Optimization.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Clinical Relevance Of Systematic CRT Device Optimization.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider