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Patients with early-stage colorectal cancer have an upbeat prognosis, and many don't even receive chemotherapy. But 30% will relapse, challenging the tenet that grape-sized tumors that haven't spread aren't an undue cause for concern. Reaching back to a theory proposed in the late 19th century, a team of French scientists now says that in that 30%, recurrence may have little to do with the tumor itself. Rather, poor prognosis could stem from a lackluster immune reaction to cancer.
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Jennifer Couzin (2006) studied this question.
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