Key result
PICC designs reduced the incidence of obstruction, but new materials did not reflect a significant reduction in overall complications.
Why the study?
Studies showed integrating coatings or valves into PICCs can prevent complications, but efficiency data remained controversial.
Do specific PICC materials and designs reduce PICC-related complications?
Meta-Analysis
Do specific PICC materials and designs reduce PICC-related complications?
Specific PICC designs may reduce catheter obstruction, but current evidence does not support a significant reduction in overall complications with new PICC materials.
Answers are grounded in this paper and cite their sources.
Supports specific PICC designs to cut obstruction; extends design evidence while challenging new materials for overall complication reduction.
Studies showed that integrating coating or valve into Peripherally Inserted Central (PICC) can prevent related complications. However, data regarding efficiency were controversial. Therefore, a systematic review was needed to analyse the effect of PICC materials and designs on reduction of PICC-related complications. We searched PubMed, Cochrane library, EMbase, grey literature and referent literature from inception to 5 August 2022. Randomized controlled trials (RCTs) and case-control study were included. Two authors extracted data independently, using a predesigned Excel form, and assessed the quality of included RCTs according to the Cochrane Handbook for Systematic Reviews (V5.1.0), case-control study was assessed by the Newcastle-Ottawa Scale. Data were analysed using Review Manager (v5.3.0). A total of 10 RCTs and one case-control study were included. Meta-analysis results showed that PICC designs reduce the incidence of obstruction, and at the critical value of PICC-associated bloodstream infection, but may have no effects on other complications. Based on the literature reviewed, we can only say PICC new materials did not reflect significant reduction on complications, what's more, the result needs more multicentre, large RCTs to support. We suggested clinicians combine descriptive research and cost-effect analysis to select appropriate PICC materials and designs for patients.
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Ding et al. (2023) conducted a meta-analysis in PICC-related complications. PICC materials and designs was evaluated on PICC-related complications. PICC designs reduced the incidence of obstruction, but new materials did not reflect a significant reduction in overall complications.
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