Key result
Optimization of ketomethylene-containing compounds provided highly active 3C protease inhibitors functioning as potent antirhinoviral agents (EC90 <1 microM) against multiple virus serotypes.
Population
Human rhinovirus (HRV) 3C protease (3CP) and multiple virus serotypes in cell culture
Comparison
Ketomethylene-containing human rhinovirus 3C… vs Corresponding peptide-derived molecules
Design
Preclinical
Authors
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These optimized inhibitors merit further preclinical testing; leaves open clinical translation for rhinovirus.
Effect estimate: EC90 <1 microM
Ketomethylene-containing peptidomimetics act as potent, irreversible inhibitors of human rhinovirus 3C protease with strong antiviral activity in cell culture.
Dragovich et al. (1999) studied Human rhinovirus (HRV) infection. Ketomethylene-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors vs. Peptide-derived molecules was evaluated on Antiviral properties (EC90) (EC90 <1 microM). Optimization of ketomethylene-containing compounds provided highly active 3C protease inhibitors functioning as potent antirhinoviral agents (EC90 <1 microM) against multiple virus serotypes.