Key result
In women, metabolic syndrome was independently associated with a parental history of combined premature MI, stroke, and angina (OR 1.79; 95% CI 1.21-2.63; P=0.003).
Cross-Sectional (n=3,441)
Yes
Odds Ratio: 1.79 (95% CI 1.21–2.63)
p-value: p=0.003
Metabolic syndrome in women is independently associated with a parental history of premature cardiovascular disease, suggesting a familial aggregation component.
May support family history assessment in women with metabolic syndrome; hypothesis-generating for intergenerational premature CVD risk.
AIMS: The goal of this study is to assess the association between the metabolic syndrome (MS) and parental history of cardiovascular disease (CVD). METHODS AND RESULTS: Participants were recruited in a population survey of 3441 men and women, aged 35-64. MS was defined with NCEP-III guidelines. Familial history of myocardial infarction (MI), angina, and stroke was assessed with a standardized questionnaire. Parental premature CVD was defined if CVD occurred before 55/65 years in the father/mother. A total of 390 men and 281 women had MS. Positive parental CVD was associated with MS in women (43.0 vs. 36.8%, P<0.001) but not in men (36.9 vs. 31.8%, P=0.06). Similarly, parental premature CVD was associated with MS in women (19.2 vs. 11.8%, P<0.0007) but not in men (11.1 vs. 11.1%, ns). In women with MS, the age, centre, and educational level adjusted odds ratios [OR (95% CI)] of having a positive parental premature stroke was 1.84 (1.0-3.38), P=0.049. This OR was 1.76 (1.23-2.76), P=0.007 for combined parental premature MI and stroke and 1.67 (1.17-2.38), P=0.004 for combined premature MI, stroke, and angina. After further adjustment on personal coronary heart disease and CVD risk factors, the ORs of having a positive parental history of combined premature MI and stroke [1.75 (1.11-2.76), P=0.016] or MI, stroke, and angina [1.79 (1.21-2.63), P=0.003], remained statistically significant, in women with MS. CONCLUSION: The MS is associated with parental premature CVD independently of classical CV risk factors, suggesting that MS is a contributor to the familial aggregation of premature CVD.
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Dallongeville et al. (2006) conducted a cross-sectional in Metabolic syndrome and parental history of premature cardiovascular disease (n=3,441). Metabolic syndrome vs. No metabolic syndrome was evaluated on Positive parental history of combined premature MI, stroke, and angina in women (OR 1.79, 95% CI 1.21-2.63, p=0.003). In women, metabolic syndrome was independently associated with a parental history of combined premature MI, stroke, and angina (OR 1.79; 95% CI 1.21-2.63; P=0.003).
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