Key result
Whole blood gene expression profiling demonstrated similar directional changes to peripheral blood mononuclear cells in patients with multiorgan dysfunction, sharing 333 significantly overlapping genes.
Why the study?
Does whole blood gene expression profiling perform similarly to PBMC profiling for evaluating the perioperative inflammatory response and multiorgan dysfunction in advanced heart failure patients?
Population
31 advanced heart failure patients undergoing cardiothoracic surgery and 7 healthy age-matched controls at a…
Comparison
Whole blood gene expression profiling using… vs Peripheral blood mononuclear cell gene…
Design
Cohort
Follow-up
median 8 days postoperatively (IQR 7-14 days)
Authors
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May support whole blood as a simpler alternative to PBMC profiling in advanced heart failure; leaves open prospective validation before clinical adoption.
Observational (n=38)
No
Does whole blood gene expression profiling perform similarly to PBMC profiling for evaluating the perioperative inflammatory response and multiorgan dysfunction in advanced heart failure patients?
Whole blood gene expression profiling performs similarly to PBMC profiling and has the potential to serve as a clinically feasible tool for immune-monitoring in advanced heart failure patients with multiorgan dysfunction.
Bondar et al. (2014) conducted an observational in Advanced Heart Failure (n=38). Whole blood gene expression profiling vs. Peripheral blood mononuclear cell (PBMC) gene expression profiling was evaluated on Direction of change and overlap in gene expression profiles between whole blood and PBMC. Whole blood gene expression profiling demonstrated similar directional changes to peripheral blood mononuclear cells in patients with multiorgan dysfunction, sharing 333 significantly overlapping genes.
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