Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice

FIGURE 1. Glucose tolerance test among the different groups in C57BL/6 mice. Note: ND, normal diet group; HFD, high‐fat diet group; HF+BGE, HFD with 100 mg/kg.bw black ginseng extract group; HF+AGE, HFD with 100 mg/kg.bw aged black garlic extract group; HF+BGE+AGE100, HFD with 100 mg/kg,bw BGE and AGE mixture group; HF+BGE+AGE150, HFD with 150 mg/kg.bw BGE and AGE mixture group; and HF+BGE+AGE200, HFD with 200 mg/kg.bw BGE and AGE mixture groups. Mean ±SE (n = 10). Experimental values were significant difference from HFD at that time using one‐way ANOVA.*p <.05, **p <.01, ***p <.001

FIGURE 2. Insulin tolerance test in different groups in C57BL/6 mice. Note: ND, normal diet group; HFD, high‐fat diet group; HF+BGE, HFD with 100 mg/kg.bw black ginseng extract group; HF+AGE, HFD with 100 mg/kg.bw aged black garlic extract group; HF+BGE+AGE100, HFD with 100 mg/kg,bw BGE and AGE mixture group; HF+BGE+AGE150, HFD with 150 mg/kg.bw BGE and AGE mixture group; and HF+BGE+AGE200, HFD with 200 mg/kg.bw BGE and AGE mixture groups. Mean ±SE (n = 10). Experimental values were significant difference from HFD at that time using one‐way ANOVA.*p <.05, **p <.01, ***p <.001

FIGURE 3. Histopathological of liver cell of mice treated with ginseng and garlic extracts. Note: (a) ND, normal diet group; (b) HFD, high‐fat diet group; (C) HF+BGE, HFD with 100 mg/kg.bw black ginseng extract group; (d) HF+AGE, HFD with 100 mg/kg.bw aged black garlic extract group; (E) HF+BGE+AGE100, HFD with 100 mg/kg,bw BGE and AGE mixture group;(f) HF+BGE+AGE150, HFD with 150 mg/kg.bw BGE and AGE mixture group; and (G) HF+BGE+AGE200, HFD with 200 mg/kg.bw BGE and AGE mixture groups