Key result
EPA and DHA supplementation for 5 weeks significantly increased HDL content of EPA and DHA and improved endothelial function in hypertriglyceridemic patients.
Why the study?
HDLs enhance vascular function by delivering functional lipids, but whether EPA and DHA content in HDLs improves these vascular effects was unknown.
Does EPA and DHA supplementation improve endothelial function and HDL composition in hypertriglyceridemic patients?
RCT (n=18)
Does EPA and DHA supplementation improve endothelial function and HDL composition in hypertriglyceridemic patients?
EPA and DHA supplementation for 5 weeks improves endothelial function and shifts HDL particles to a more anti-inflammatory profile in hypertriglyceridemic patients.
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Supports EPA/DHA supplementation to improve endothelial function in hypertriglyceridemia; extends evidence on HDL fatty acid enrichment.
Peña-de-la-Sancha et al. (2023) conducted an RCT in Hypertriglyceridemia (n=18). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) vs. Placebo was evaluated on Endothelial function assessed using flow-mediated dilatation (FMD) and HDL fatty acid content. EPA and DHA supplementation for 5 weeks significantly increased HDL content of EPA and DHA and improved endothelial function in hypertriglyceridemic patients.
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