Key result
In patients with severe cardiogenic shock requiring a vasopressor, the addition of an inodilator to an inopressor was associated with improved short-term mortality (HR 0.66) compared to inopressors alone.
Why the study?
Does the addition of an inodilator to an inopressor reduce short-term mortality in patients with severe cardiogenic shock?
Population
988 patients with severe cardiogenic shock from a pooled cohort of 1,272 patients with decompensated heart…
Comparison
Combination of an inopressor and an inodilator vs Inopressors alone
Design
Cohort
Follow-up
30 days
Authors
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Should not yet change vasopressor strategies in shock; hypothesis-generating and requires randomized confirmation.
Observational (n=988)
Yes
Does the addition of an inodilator to an inopressor reduce short-term mortality in patients with severe cardiogenic shock?
Hazard Ratio: 0.66 (95% CI 0.55–0.8)
Absolute Event Rate: 60% vs 72%
In patients with severe cardiogenic shock requiring vasopressors, adding an inodilator to an inopressor may significantly reduce 30-day mortality compared to using inopressors alone.
Pirracchio et al. (2013) conducted an observational in Severe cardiogenic shock (n=988). Inopressors plus inodilators vs. Inopressors alone was evaluated on Short-term mortality (up to day 30) (HR 0.66, 95% CI 0.55-0.80). In patients with severe cardiogenic shock requiring a vasopressor, the addition of an inodilator to an inopressor was associated with improved short-term mortality (HR 0.66) compared to inopressors alone.
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