Key result
Patients with dilated cardiomyopathy had a significantly higher percentage of apoptotic myocytes compared to controls (6.4% vs 0%, p<0.05), and increased Fas expression correlated with the severity of left ventricular systolic impairment.
Why the study?
Do Fas expression and apoptosis correlate with cardiac dysfunction in patients with dilated cardiomyopathy?
Case-Control (n=19)
Blinded assessors
No
Do Fas expression and apoptosis correlate with cardiac dysfunction in patients with dilated cardiomyopathy?
Absolute Event Rate: 6.4% vs 0%
p-value: p=<0.05
Fas expression and apoptosis are significantly increased in the myocardium of patients with dilated cardiomyopathy and correlate with the severity of left ventricular systolic dysfunction.
No takes yet. Share an insight, caveat, or question.
Apoptosis and Fas upregulation associate with LV impairment in DCM; hypothesis-generating and should not yet change practice.
Yamamura et al. (1999) conducted a case-control in Dilated Cardiomyopathy (n=19). Dilated cardiomyopathy vs. Control subjects without dilated cardiomyopathy was evaluated on Percentage of in situ TdT-positive (apoptotic) myocytes (p=<0.05). Patients with dilated cardiomyopathy had a significantly higher percentage of apoptotic myocytes compared to controls (6.4% vs 0%, p<0.05), and increased Fas expression correlated with the severity of left ventricular systolic impairment.
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