Key result
Propranolol and timolol induced a dose-dependent decrease in myocardial contractility and stimulus conduction in isolated rat hearts, whereas sotalol showed slight cardiodepressant activity.
Why the study?
Do different beta-blocking agents (propranolol, timolol, sotalol) have different cardiotoxic profiles on cardiac function in isolated rat hearts?
Population
Isolated, perfused and catecholamine depleted rat hearts
Design
Preclinical
Authors
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Does not support changes in clinical beta-blocker selection; leaves open lipophilicity as a driver of differential effects in animal models.
Do different beta-blocking agents (propranolol, timolol, sotalol) have different cardiotoxic profiles on cardiac function in isolated rat hearts?
The cardiotoxic profile of beta-blockers in isolated rat hearts varies significantly, potentially driven by lipophilicity rather than beta-adrenoceptor blockade or membrane stabilizing activity.
Wildt et al. (1984) studied Isolated rat hearts. Propranolol, timolol, and sotalol was evaluated on Myocardial contractility, stimulus formation and stimulus conduction. Propranolol and timolol induced a dose-dependent decrease in myocardial contractility and stimulus conduction in isolated rat hearts, whereas sotalol showed slight cardiodepressant activity.
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